Road traffic safety has emerged as an urban mobility and development issue for African cities throughout time. To establish a comprehensive road safety reform within cities, one needed to be familiar with the political and legal environment, institutional responsibilities, and stakeholders. Road safety reform, though, is not without its issues. This study aims to prioritize Nairobi's road safety strategies to achieve zero traffic injuries. Four road safety reform challenges were examined based on the opinions of three experts. The Ordinal Priority Approach (OPA) was used to calculate the weights and ranks of experts, alternatives, and criteria, simultaneously. The findings of the study indicated that lack of political priority given to road safety reform is the most significant challenge, while the lack of coordination among different government agencies is the least challenge. The findings of the study also indicated that the top three strategies for successfully enacting a road safety reform are to take advantage of broad institutional and governance reform, reframe the road safety in political and public debate, and bundle the road safety with other important public issues.