The primary objective of this study is to identify and optimize the critical variables that influence the operational effectiveness of warehouses. This study adds to previous research by providing a deeper understanding of how these factors affect operational effectiveness. Specifically, it is found that insufficient workforce numbers have a negative effect on operational performance and increase expenses. These findings contribute to the existing body of knowledge and emphasize the importance of considering these variables when optimizing warehouse operations, thereby increasing productivity and efficiency. SPSS is used as the analysis tool to examine the relationships between Warehouse Operations Efficiency (WOE) and various parameters. The findings demonstrate strong positive relationships between all of the variables. These findings demonstrate the importance of warehouse optimization in boosting productivity and efficiency. Aspects that affect operational efficiency include staffing levels, personnel skill sets, communication throughout the supply chain network, material handling technology, and inventory management systems. The report also discusses warehouse layout issues, such as inefficient picking metrics, unnecessary motions, safety and security concerns, dead-end aisles, and inadequate overflow space. The study also identifies supply chain visibility obstacles, limited resources, and resistance to technological advancements as obstacles to achieving warehouse operating efficiency.